Factor 8

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Professor Francis Eric Preston

Factor 8

Para 14 WS - Would you accept that cryo was used for the treatment of severe haemophiliacs prior to the advent of concentrates?

  • In 1980, Preston is named in presenting this information to the Glasgow Symposium (Unresolved problems in haemophilia book) https://drive.google.com/file/d/1PmfOeNoqvGBaZrhGGfjcDge56iIFfzAp/view?usp=sharing

    • In the resulting discussion about Hep C and liver damage, Dr Triger says "I think we are just building up to trouble" and Dr Thomas says "it will be an enormous problem when it happens". https://drive.google.com/file/d/1-uQzchIuS6Z6qUCyc_pD0nHKzdJ51BMK/view?usp=sharing

      • What is Preston’s recollection of this?

      • Were patients informed that they were building up to trouble and enormous problems were coming?

      • For how long had Dr Triger held this view?

  • Para 89 WS - Why?

  • Para 143 WS - Does he accept that HIV prevalence was higher in the USA than in the UK during the early 1980s?

  • Para 145 WS - Why was this possible before the advent of concentrate but he feels it was not after?

  • Para 154 WS - Could this have been in relation to trials of Kryobulin?

  • In relation to the following document, Preston was present at this meeting in 12th Feb 1990 where HS request for liver damage data was cited. Further it is noted that Preston said questionnaires had been sent out. https://www.dropbox.com/s/j1yhk8jqqrc596t/8_4_9.UK%20Regional%20HCDO%2019900212.pdf?dl=0

    • What does he recall about the discussion on the HS request for data?

    • What were the results of the 66 returned questionnaires?

  • On the same day, 12th Feb 1990, Preston attends the following linked meeting which discusses the HIV litigation somewhat in depth. https://drive.google.com/file/d/1v4fW6xCG0YdnFVZHLiZMJNdp8JW_EtFl/view?usp=sharing

    • "Prof Preston thought that the problem went beyond HIV and that the discussion of liver disease in view of the haemophilia society's request for information might prove very awkward if an expert witness of the plaintiffs was present" (page 2) - Why???

    • What does he remember about why it was said here that the haemophilia society “should not be given hepatitis data”? (page 4)

    • Can he comment on the data he shared that 20% of spouses of haemophiliacs were infected with hep c? (page 5)